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KMID : 0356620110260030239
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Journal of Korean Society of Endocrinology
2011 Volume.26 No. 3 p.239 ~ p.242
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A Case of Adrenocortical Carcinoma Secreting Cortisol, Androgen and Aldosterone
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Choi Jae-Ho
So Ye-Ri
Hwang You-Chul
Jeong In-Kyung
Ahn Kyu-Jeung
Chung Ho-Yeon
Yang Seung-Ae
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Abstract
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Primary adrenocortical carcinoma is a rare tumor, and is characterized by a peri-tumor mass effect and hormone excess signs. Adrenocortical carcinoma most commonly secretes cortisol, but tumors that secrete other adrenal hormones (aldosterone, androgen) are rare. Herein, we report the case of a 70-year-old woman with cortisol, androgen, and aldosterone-secreting adrenal carcinoma. The patient complained of generalized weakness, moon face, and central obesity. On laboratory examination, hypokalemia and metabolic alkalosis was detected. On the hormone test, cortisol, DHEA-S, and aldosterone were all increased. Abdominal CT showed a large right adrenal mass. She underwent right adrenalectomy and the histology revealed the presence of an adrenocortical carcinoma. After adrenalectomy, the patient was treated with hydrocortisone and mitotane.
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KEYWORD
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Adrenocortical carcinoma, Androgen, Cortisol, Cushing’s syndrome, Primary aldosteronism
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